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PF-04929113 (SNX-5422)

CAT: 0607-A4065-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0607-A4065-5Size:5 mg
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Description
Hsp90 inhibitor,potent and selective
CAS Number
908115-27-5
Product Name Alternative
[4-[2-carbamoyl-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]anilino]cyclohexyl] 2-aminoacetate
Field of Research
Metabolism HSP Proteases HSP
Purity
0.9961
Form
A solid
Solubility
≥23.85 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
Smiles
CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)OC(=O)CN)C(F)(F)F)C
Molecular Formula
C25H30F3N5O4
Molecular Weight
521.5
Shipping Conditions
Blue ice
Storage Conditions
Store at -20°C.

Chemical Information

Snx-5422

SNX-5422 is a synthetic, novel, small molecule Hsp90 Inhibitor. As an oral formulation that demonstrates strong efficacy and tolerability, SNX-5422 is positioned as a breakthrough therapy with broad applicability across a wide range of cancers.

CAS Number908115-27-5
PubChem CID44195571
IUPAC Name[4-[2-carbamoyl-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]anilino]cyclohexyl] 2-aminoacetate
Molecular FormulaC25H30F3N5O4
Molecular Weight521.5
XLogP3.5
Topological Polar Surface Area142
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Heavy Atom Count37
Formal Charge0
Complexity877
SMILES
CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)OC(=O)CN)C(F)(F)F)C
InChI
InChI=1S/C25H30F3N5O4/c1-24(2)10-18-21(19(34)11-24)22(25(26,27)28)32-33(18)14-5-8-16(23(30)36)17(9-14)31-13-3-6-15(7-4-13)37-20(35)12-29/h5,8-9,13,15,31H,3-4,6-7,10-12,29H2,1-2H3,(H2,30,36)
InChIKey
AVDSOVJPJZVBTC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Snx-5422
CAS: 908115-27-5
CID: 44195571
Formula: C25H30F3N5O4
MW: 521.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight521.5
XLogP33.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Exact Mass521.22498894
Monoisotopic Mass521.22498894
Topological Polar Surface Area142 Ų
Heavy Atom Count37
Formal Charge0
Complexity877
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
C16977-10mM/1mLPF-04929113 (SNX-5422)
A11074-25PF-04929113 (SNX-5422) 25mg
A11074-2PF-04929113 (SNX-5422) 2mg
A11074-1PF-04929113 (SNX-5422) 1mg
A11074-10mM-DPF-04929113 (SNX-5422) 10mM * 1mL in DMSO
SC0123-10mMSNX-2112 (PF-04928473)
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FP104240-01PF 04929113

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