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SU 5402

CAT: 0607-A3843-10Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0607-A3843-10Size:10 mg
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Description
VEGFR2/FGFR/PDGFR/EGFR inhibitor
CAS Number
215543-92-3
Product Name Alternative
3-[4-methyl-2-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid
Sequence
SU-5402; SU5402
Field of Research
Tyrosine Kinase VEGFR
Purity
0.9848
Form
A solid
Solubility
insoluble in EtOH; insoluble in H2O; ≥14.8 mg/mL in DMSO
Smiles
CC1=CNC(=C1CCC(=O)O)C=C2C3=CC=CC=C3NC2=O
Molecular Formula
C17H16N2O3
Molecular Weight
296.33
Shipping Conditions
Blue ice
Storage Conditions
Store at -20°C.

Chemical Information

Su5402

SU5402 is an oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is substituted by a 3-(2-carboxyethyl)-4-methyl-1H-pyrrol-2-yl group. It is an ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1. It has a role as a fibroblast growth factor receptor antagonist. It is a monocarboxylic acid, a member of pyrroles and a member of oxindoles. It is functionally related to a 3-methyleneoxindole.

CAS Number215543-92-3
PubChem CID5289418
IUPAC Name3-[4-methyl-2-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid
Molecular FormulaC17H16N2O3
Molecular Weight296.32
XLogP1.8
Topological Polar Surface Area82.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count22
Formal Charge0
Complexity488
SMILES
CC1=CNC(=C1CCC(=O)O)/C=C\2/C3=CC=CC=C3NC2=O
InChI
InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
InChIKey
JNDVEAXZWJIOKB-JYRVWZFOSA-N
Chemical Structure
2D Structure
2D structure of Su5402
CAS: 215543-92-3
CID: 5289418
Formula: C17H16N2O3
MW: 296.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight296.32
XLogP31.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass296.11609238
Monoisotopic Mass296.11609238
Topological Polar Surface Area82.2 Ų
Heavy Atom Count22
Formal Charge0
Complexity488
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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