ABT-263 (Navitoclax)

• Description:

  Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w

• Product Name Alternative:

  (R)-4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide

• Sequence:

  Navitoclax,ABT-263,ABT263,ABT 263

• Field of Research:

  Apoptosis Bcl-2 Family

• Purity:

  0.9854

• Solubility:

  ≥48.73 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O

• Smiles:

  CC(CC1)(C)CC(CN2CCN(C3=CC=C(C(NS(C4=CC=C(N[C@@H](CSC5=CC=CC=C5)CCN6CCOCC6)C(S(C(F)(F)F)(=O)=O)=C4)(=O)=O)=O)C=C3)CC2)=C1C7=CC=C(Cl)C=C7

• Molecular Formula:

  C47H55ClF3N5O6S3

• Molecular Weight:

  974.61

• Shipping Conditions:

  Blue ice

• Storage Conditions:

  Desiccate at -20°C.

• CAS Number:

  923564-51-6