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Oprozomib (ONX-0912)

CAT: 0607-A1934-100Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0607-A1934-100Size:100 mg
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Description
Proteasome inhibitor
CAS Number
935888-69-0
Product Name Alternative
N-[(2S)-3-methoxy-1-[[(2S)-3-methoxy-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
Sequence
ONX-0912,ONX0912,ONX 0912,PR 047,Oprozomib
Field of Research
Ubiquitination Proteasome Proteasome
Purity
0.9763
Form
A solid
Solubility
≥26.6 mg/mL in DMSO; insoluble in H2O; ≥2.77 mg/mL in EtOH with gentle warming and ultrasonic
Smiles
CC1=NC=C(S1)C(=O)NC(COC)C(=O)NC(COC)C(=O)NC(CC2=CC=CC=C2)C(=O)C3(CO3)C
Molecular Formula
C25H32N4O7S
Molecular Weight
532.61
Shipping Conditions
Blue ice
Storage Conditions
Desiccate at -20°C.

Chemical Information

Oprozomib

Oprozomib has been used in trials studying the treatment of Solid Tumors, Multiple Myeloma, Waldenstrom Macroglobulinemia, Advanced Hepatocellular Carcinoma, and Advanced Non-Central Nervous System (CNS) Malignancies.

CAS Number935888-69-0
PubChem CID25067547
IUPAC NameN-[(2S)-3-methoxy-1-[[(2S)-3-methoxy-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
Molecular FormulaC25H32N4O7S
Molecular Weight532.6
XLogP1.1
Topological Polar Surface Area176
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count14
Heavy Atom Count37
Formal Charge0
Complexity825
SMILES
CC1=NC=C(S1)C(=O)N[C@@H](COC)C(=O)N[C@@H](COC)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)[C@]3(CO3)C
InChI
InChI=1S/C25H32N4O7S/c1-15-26-11-20(37-15)24(33)29-19(13-35-4)23(32)28-18(12-34-3)22(31)27-17(21(30)25(2)14-36-25)10-16-8-6-5-7-9-16/h5-9,11,17-19H,10,12-14H2,1-4H3,(H,27,31)(H,28,32)(H,29,33)/t17-,18-,19-,25+/m0/s1
InChIKey
SWZXEVABPLUDIO-WSZYKNRRSA-N
Chemical Structure
2D Structure
2D structure of Oprozomib
CAS: 935888-69-0
CID: 25067547
Formula: C25H32N4O7S
MW: 532.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight532.6
XLogP31.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count14
Exact Mass532.19917055
Monoisotopic Mass532.19917055
Topological Polar Surface Area176 Ų
Heavy Atom Count37
Formal Charge0
Complexity825
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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