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Meclizine

CAT: 0804-HY-B0349A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0349A-01Size:1 mg
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Description
Meclizine (Meclozine), an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine is a member of the piperazine class of H1 antagonists. Meclizine is an effective anti-motion sickness agent. Meclizine crosses the blood–brain barrier. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR. Meclizine can be used for the research of polyQ toxicity disorders, such as Huntington's disease[1][2][3].
CAS Number
569-65-3
Product Name Alternative
Meclozine
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; Histamine Receptor
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/meclizine.html
Solubility
10 mM in DMSO
Smiles
CC1=CC(CN2CCN(C(C3=CC=C(Cl)C=C3)C4=CC=CC=C4)CC2)=CC=C1
Molecular Formula
C25H27ClN2
Molecular Weight
390.95
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Priti N. Patel, et al. Safety and Efficacy in the Treatment and Prevention of Motion Sickness.|[2]Vishal M Gohil, et al. Meclizine is neuroprotective in models of Huntington's disease. Hum Mol Genet. 2011 Jan 15;20 (2) :294-300.|[3]Seiji Kishi, et al. Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury. EBioMedicine. 2015 Jul 29;2 (9) :1090-101.|[4]Wendong Huang, et al. Meclizine Is an Agonist Ligand for Mouse Constitutive Androstane Receptor (CAR) and an Inverse Agonist for Human CAR
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
H1 Receptor
Citation 01
Am J Obstet Gynecol. 2024 Jul;231 (1) :113.e1-113.e13.|J Biochem Mol Toxicol. 2025 Aug;39 (8) :e70420.|Ren Fail. 2023 Dec;45 (1) :2230318.

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