APETx2

• Description:

  APETx2, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible ASIC3 inhibitor, with an IC50 of 63 nM. APETx2 directly inhibits the ASIC3 channel by acting at its external side. APETx2 could reverses acid‐induced and inflammatory pain[1][2].

• UNSPSC:

  12352209

• Target:

  Sodium Channel

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/apetx2.html

• Solubility:

  H2O

• Smiles:

  O=C (N[C@@H] ([C@H] (O) C) C (N[C@@H] (C) C (N[C@@H] (CSSC[C@@H]1NC2=O) C (N[C@@H] (CO) C (N[C@@H] (CSSC[C@@H] (C (N[C@@H] (CCCNC (N) =N) C (N[C@@H] (CC3=CC=C (C=C3) O) C (N[C@@H] (CC4=CC=CC=C4) C (N[C@@H] (CC (C) C) C (NCC (N[C@H]2[C@H] (O) C) =O) =O) =O) =O) =O) =O) NC5=O) C (NCC (N[C@@H] (CC (N) =O) C (N[C@@H] (CO) C (N[C@@H] (CCCCN) C (NCC (N[C@@H] ([C@@H] (C) CC) C (N[C@@H] (CC6=CC=C (C=C6) O) C (N[C@@H] (CC7=CNC8=CC=CC=C78) C (N[C@@H] (CC9=CC=CC=C9) C (N[C@@H] (CC%10=CC=C (C=C%10) O) C (N[C@@H] (CCCNC (N) =N) C (N%11[C@@H] (CCC%11) C (N[C@@H] (CO) C (N[C@@H] (CSSC[C@@H] (C (N[C@@H] ([C@H] (O) C) C (N%12[C@@H] (CCC%12) C (N[C@@H] (C) C (N[C@@H] (CC (O) =O) C (O) =O) =O) =O) =O) =O) NC1=O) C (N%13[C@@H] (CCC%13) C (N[C@@H] ([C@H] (O) C) C (N[C@@H] (CC (O) =O) C (N[C@@H] (CCCNC (N) =N) C (NCC (N[C@@H] (CC%14=CC=C (C=C%14) O) C (N[C@@H] ([C@H] (O) C) C (NCC (N[C@H]5CO) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) CN

• Molecular Formula:

  C196H280N54O61S6

• Molecular Weight:

  4561.00

• References & Citations:

  [1]Sylvie Diochot, et al. A New Sea Anemone Peptide, APETx2, Inhibits ASIC3, a Major Acid-Sensitive Channel in Sensory Neurons. EMBO J. 2004 Apr 7;23 (7) :1516-25.|[2]Jerzy Karczewski, et al. Reversal of Acid-Induced and Inflammatory Pain by the Selective ASIC3 Inhibitor, APETx2. Br J Pharmacol. 2010 Oct;161 (4) :950-60.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  713544-47-9