9-Hydroxyoctadecanoic acid

• Description :

  9-Hydroxyoctadecanoic acid (9-HSA) is an HDAC1 inhibitor that inhibits ∼66.4% HDAC1 enzymatic activity at 5 μM. 9-Hydroxyoctadecanoic acid shows anticancer activity[1].

• Product Name Alternative :

  9-Hydroxystearic acid; 9-HSA

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  HDAC

• Type :

  Natural Products

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/9-hydroxyoctadecanoic-acid.html

• Purity :

  98.0

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C(CCCCCCCC(CCCCCCCCC)O)O

• Molecular Formula :

  C18H36O3

• Molecular Weight :

  300.48

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Calonghi N, et al. Histone deacetylase 1: a target of 9-hydroxystearic acid in the inhibition of cell growth in human colon cancer. J Lipid Res. 2005 Aug;46 (8) :1596-603.|[2]Calonghi N, et al. 9-Hydroxystearic acid upregulates p21 (WAF1) in HT29 cancer cells. Biochem Biophys Res Commun. 2004 Jan 30;314 (1) :138-42.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  HDAC1

• CAS Number :

  [3384-24-5]