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PSN632408

CAT: 0804-HY-16673-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16673-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PSN632408, a selective, orally active GPR119 agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50=5.6 and 7.9 uM, respectively) . PSN632408 can stimulate β-cell replication and improve islet graft function. PSN632408 has the potential for the research of obesity and related metabolic disorders[1][2].
CAS Number
857652-30-3
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
GPR119
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/PSN632408.html
Purity
99.30
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(OC(C)(C)C)N1CCC(CC1)OCC2=NC(C3=CC=NC=C3)=NO2
Molecular Formula
C18H24N4O4
Molecular Weight
360.41
Precautions
H315, H319, H320
References & Citations
[1]Gao J, et al. Stimulating beta cell replication and improving islet graft function by GPR119 agonists. Transpl Int. 2011;24 (11) :1124-1134.|[2]Overton HA, et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006;3 (3) :167-175.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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