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Ercalcitriol

CAT: 0804-HY-32350-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-32350-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases[1][2].
CAS Number
60133-18-8
Product Name Alternative
1α,25-Dihydroxy Vitamin D2
UNSPSC
12352211
Hazard Statement
H301+H311, H330, H372
Target
Drug Metabolite; Endogenous Metabolite; VD/VDR
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Ercalcitriol.html
Purity
99.42
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C=C1[C@H](C[C@@H](C/C1=C/C=C2[C@]3([C@@](C)([C@H](CC3)[C@@H](/C=C/[C@@H](C(C)(O)C)C)C)CCC/2)[H])O)O
Molecular Formula
C28H44O3
Molecular Weight
428.65
Precautions
H301+H311, H330, H372
References & Citations
[1]Mawer EB, et al. A sensitive radioimmunoassay using a monoclonal antibody that is equipotent for ercalcitriol and calcitriol (1,25-dihydroxy vitamin D2 and D3) .Clin Chim Acta. 1990 Oct 15;190 (3) :199-209.|[2]Tada H, et al. Vitamin D3 analog maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells. Biomed Res. 2016;37 (3) :199-205.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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