Olaparib-d8

• Description :

  Olaparib-d8 (AZD2281-d8) is the deuterium labeled Olaparib (HY-10162) . Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[1][2][3][4].

• Product Name Alternative :

  AZD2281-d8; KU0059436-d8

• UNSPSC :

  12352005

• Target :

  Autophagy; Isotope-Labeled Compounds; Mitophagy; PARP

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Autophagy; Cell Cycle/DNA Damage; Epigenetics; Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Purity :

  99.57

• Solubility :

  DMF : 50mg/mL (ultrasonic) |DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 3.12mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C1NN=C(CC2=CC=C(F)C(C(N3C([2H])([2H])C([2H])([2H])N(C(C4CC4)=O)C([2H])([2H])C3([2H])[2H])=O)=C2)C5=C1C=CC=C5

• Molecular Formula :

  C24H15D8FN4O3

• Molecular Weight :

  442.51

• References & Citations :

  [1]Menear KA, et al. 4-[3- (4-cyclopropanecarbonylpiperazine-1-carbonyl) -4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly (ADP-ribose) polymerase-1. J Med Chem. 2008 Oct 23;51 (20) :6581-91|[2]Senra JM, et al. Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.Mol Cancer Ther. 2011 Oct;10 (10) :1949-58.|[3]Yasukawa M, et al. Synergetic Effects of PARP Inhibitor AZD2281 in Oral Squamous Cell Carcinoma in Vitro and in Vivo. Int J Mol Sci. 2016 Feb 24;17 (3) :272.|[4]Bian X, et al. PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy. Oncogene. 2018 Jan 18;37 (3) :341-351.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported