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Linderalactone

CAT: 0804-HY-N0781-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0781-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Linderalactone is an important sesquiterpene lactone isolated from Lindera aggregata. Linderalactone inhibits cancer growth by modulating the expression of apoptosis-related proteins and inhibition of JAK/STAT signalling pathway. Linderalactone also inhibits the proliferation of the lung cancer A-549 cells with an IC50 of 15 μM[1][2].
CAS Number
728-61-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/linderalactone.html
Concentration
10mM
Purity
99.96
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C1C2=C[C@@](C3=C(OC=C3C)C/C(C)=C/CC2)([H])O1
Molecular Formula
C15H16O3
Molecular Weight
244.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Deng Y, et al. Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins, G2/M cell cycle arrest and inhibition of JAK/STAT signalling pathway. J BUON. 2019 Mar-Apr;24 (2) :566-571.|[2]Qinghua Sun, et al. Preparative Isolation and Purification of Linderalactone and Lindenenol from Radix linderae by HSCCC. Journal of Liquid Chromatography & Related Technologies. Aug 2005:113-121.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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