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BCH001

CAT: 0804-HY-137817-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-137817-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BCH001, a quinoline derivative, is a specific PAPD5 inhibitor. BCH001 restores telomerase activity and telomere length in dyskeratosis congenita (DC) induced pluripotent stem cells. BCH001 shows no inhibition of poly (A) -specific ribonuclease (PARN) or several other canonical and non-canonical polynucleotide polymerases. BCH001 is used to regulate aging[1].
CAS Number
384859-58-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bch001.html
Purity
98.83
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=C(NC2=CC=CC=C2C(O)=O)C3=CC(OC(F)(F)F)=CC=C3N=C1)OCC
Molecular Formula
C20H15F3N2O5
Molecular Weight
420.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Neha Nagpal, et al. Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells. Cell Stem Cell. 2020 Jun 4;26 (6) :896-909.e8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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