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Cladophorol A

CAT: 0804-HY-N15159Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N15159Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cladophorol A is a cGAS inhibitor that binds to the conserved adenosine nucleobase binding site of cGAS, thereby blocking its activity. At non-cytotoxic concentrations, Cladophorol A effectively inhibits the overactivation of the cGAS-STING pathway with an IC50 of 370 nM. Cladophorol A holds potential for research on inflammatory diseases related to the overactivation of the cGAS-STING pathway[1].
CAS Number
146776-30-9
UNSPSC
12352005
Target
Cyclic GMP-AMP Synthase; STING
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cladophorol-a.html
Smiles
O=C1OC2=CC(O)=C(C=C2C3=C1C=C(O)C(O)=C3)O
Molecular Formula
C13H8O6
Molecular Weight
260.20
References & Citations
[1]Kissai M, et al. Cladophorol-A is an inhibitor of cyclic GMP-AMP synthase. Bioorg Med Chem Lett. 2025 Jan 1;115:130007.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
GTR19241110-01Cladophorol A

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