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Broxyquinoline

CAT: 0804-HY-B1212-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-B1212-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Broxyquinoline (Dibromohydroxyquinoline) is an effective inhibitor of severe fever with thrombocytopenia syndrome virus (SFTSV) with an IC50 of 5.8 µM. Additionally, Broxyquinoline is an inhibitor of CpACBP1 with an IC50 of 64.9 μM. CpACBP1 is a fatty acyl-CoA binding protein of Cryptosporidium parvum, thus Broxyquinoline has the potential to inhibit parasite growth. Broxyquinoline shows promise for research in the field of infectious diseases[1][2].
CAS Number
521-74-4
Product Name Alternative
Dibromohydroxyquinoline; 5,7-Dibromo-8-hydroxyquinoline
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Influenza Virus; Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Broxyquinoline.html
Purity
99.93
Solubility
DMSO : 31.25 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
OC1=C2N=CC=CC2=C(Br)C=C1Br
Molecular Formula
C9H5Br2NO
Molecular Weight
302.95
Precautions
H315, H319, H335
References & Citations
[1]Fritzler JM, et al. Novel anti-Cryptosporidium activity of known drugs identified by high-throughput screening against parasite fatty acyl-CoA binding protein (ACBP) . J Antimicrob Chemother. 2012 Mar;67 (3) :609-17.|[2]Shuofeng Yuan, et al. Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus. Viruses. 2019 Apr 25;11 (4) :385.|[3]Swetha R, et al. Organ directed toxicity of halquinol in a repeated dose 28 day oral toxicity study in female rats[J]. Indian Journal of Pharmacology, 2007, 39 (2) : 97-102.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched

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GTR19176078-01Broxyquinoline
A15626-1000Broxyquinoline 1g
A15626-100Broxyquinoline 100mg
A15626-500Broxyquinoline 500mg
A15626-250Broxyquinoline 250mg
A15626-10mM-DBroxyquinoline 10mM * 1mL in DMSO

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