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Fialuridine

CAT: 0804-HY-118122-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118122-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fialuridine (FIAU), a nucleoside analog, is a HSV-1 and HSV-2 inhibitor with Kis of 0.14 μM and 0.95 μM, respectively. Fialuridine shows anti-orthopoxvirus and anti-hepatitis B virus (HBV) activities. Fialuridine inhibits duck HBV DNA replication with IC50 values of 0.075 μM and 156 μM in human hepatoma cells and in chicken liver cells, respectively[1][2][3].
CAS Number
69123-98-4
Product Name Alternative
FIAU; DRG-0098; NSC 678514
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis; HBV; HSV; Nucleoside Antimetabolite/Analog; Orthopoxvirus
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/fialuridine.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@H](F)[C@H](N2C(NC(C(I)=C2)=O)=O)O[C@@H]1CO
Molecular Formula
C9H10FIN2O5
Molecular Weight
372.09
Precautions
H302, H315, H319, H335
References & Citations
[1]Mansuri MM, et al. 1- (2-Deoxy-2-fluoro-beta-D-arabinofuranosyl) -5-ethyluracil. A highly selective antiherpes simplex agent. J Med Chem. 1987 May;30 (5) :867-71. |[2]Mark N Prichard, et al. Orthopoxvirus targets for the development of antiviral therapies. Curr Drug Targets Infect Disord. 2005 Mar;5 (1) :17-28. |[3]Staschke KA, et al. The in vitro anti-hepatitis B virus activity of FIAU [1- (2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl-5-iodo) uracil] is selective, reversible, and determined, at least in part, by the host cell. Antiviral Res. 1994 Jan;23 (1) :45-61.|[4]Richardson FC, et al. Fialuridine accumulates in DNA of dogs, monkeys, and rats following long-term oral administration. Proc Natl Acad Sci U S A. 1994 Dec 6;91 (25) :12003-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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MBS6046007-012'-epi-Fialuridine

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