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Posdinemab

CAT: 0804-HY-P9995-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P9995-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Posdinemab (JNJ-63733657) is a humanized IgG1/κ monoclonal antibody that selectively targets phosphorylated tau (pT217) . Posdinemab specifically binds to the pT217+tau epitope rich in the proline domain, blocks tau protein aggregation and seed propagation, and promotes the clearance of extracellular tau species. Posdinemab reduces the levels of free and total p217+tau in cerebrospinal fluid, thereby inhibiting the pathological propagation of tau protein and the formation of neurofibrillary tangles. Posdinemab can be used for the study of progressive supranuclear palsy syndrome and Alzheimer's disease (AD), especially for prodromal or mild AD disease[1][2][3].
CAS Number
2517973-04-3
Product Name Alternative
JNJ-63733657
UNSPSC
12352203
Target
Tau Protein
Type
Inhibitory Antibodies
Related Pathways
Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/posdinemab.html
Purity
99.0
Solubility
10 mM in DMSO|H2O
Smiles
[Posdinemab]
Molecular Weight
(145.331 kDa)
References & Citations
[1]Galpern WR, et al. Phase 1 Studies of the Anti-Tau Monoclonal Antibody JNJ-63733657 in Healthy Participants and Participants with Alzheimer's Disease. J Prev Alzheimers Dis. 2024;11 (6) :1592-1603.|[2]Bijttebier S, et al. Development of immunoprecipitation - two-dimensional liquid chromatography-mass spectrometry methodology as biomarker read-out to quantify phosphorylated tau in cerebrospinal fluid from Alzheimer disease patients. J Chromatogr A. 2021 Aug 16;1651:462299.|[3]Panza F, et al. Clinical development of passive tau-based immunotherapeutics for treating primary and secondary tauopathies. Expert Opin Investig Drugs. 2023 Jul-Dec;32 (7) :625-634.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2

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