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Afloqualone

CAT: 0804-HY-B1833-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1833-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Afloqualone (HQ-495) is an orally active central muscle relaxant and antivertiginous agent that can increase the sensitivity of GABA receptors in neurons of the lateral vestibular nucleus. Afloqualone (HQ-495) can be used in the research of low back pain and neck-arm-shoulder syndrome[1][2][3].
CAS Number
56287-74-2
Product Name Alternative
HQ-495
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Afloqualone.html
Purity
99.94
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
O=C1N(C2=CC=CC=C2C)C(CF)=NC3=C1C=C(N)C=C3
Molecular Formula
C16H14FN3O
Molecular Weight
283.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Y Kudo, et al. Effects of afloqualone on vestibular nystagmus and the lateral vestibular nucleus. Jpn J Pharmacol. 1989 Aug;50 (4) :515-9.|[2]A INOUE, et al. Clinical Effect of Afloqualone (HQ-495) on Low Back Pain and Neck-Arm-Shoulder Syndrome By a Double Blind Trial in Comparison with Tolperisone. Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, 1981, 12 (1) : 137-154.|[3]T Ochiai, et al. Pharmacological studies on 6-amino-2-fluoromethyl-3- (O-tolyl) -4 (3H) -quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity. Jpn J Pharmacol. 1982 Jun;32 (3) :427-38.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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