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O-Demethyltramadol

CAT: 0804-HY-109054Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-109054Size:1 Each
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Description
O-Demethyltramadol is a primary active metabolite of Tramadol. O-Demethyltramadol is mainly responsible for its µ-opioid receptor-related analgesic effect. Tramadol is metabolized to O-Demethyltramadol mainly by the cytochrome P450 (CYP) 2D6 enzyme[1].
CAS Number
80456-81-1
UNSPSC
12352005
Hazard Statement
H301-H336-H411
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/o-demethyltramadol.html
Solubility
10 mM in DMSO
Smiles
O[C@@](CCCC1)(C2=CC(O)=CC=C2)[C@H]1CN(C)C
Molecular Formula
C15H23NO2
Molecular Weight
249.35
Precautions
P261-P264-P270-P271-P273-P304+P340-P330-P391-P403+P233-P405-P501
References & Citations
[1]Lee J, et al. Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6. Drug Des Devel Ther. 2019;13:1751-1761.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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