Thalidomide-PEG2-C2-NH2 (hydrochloride)
CAT:
804-HY-129703B-04
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Thalidomide-PEG2-C2-NH2 (hydrochloride)
- Product Name Alternative: Thalidomide-NH-PEG2-C2-NH2 (hydrochloride)
- CAS Number: 2245697-87-2
- UNSPSC Description: Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].
- Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
- Type: Reference compound
- Related Pathways: Apoptosis;Autophagy;PROTAC
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/thalidomide-nh-peg2-c2-nh2-hydrochloride.html
- Purity: 99.89
- Solubility: 10 mM in DMSO
- Smiles: O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCN)=O.[H]Cl
- Molecular Weight: 440.88
- References & Citations: [1]Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: No Development Reported