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ST1936

CAT: 0804-HY-103110-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103110-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ST1936 is a selective, nanomolar affinity 5-HT6 receptor agonist with Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively. ST1936 also shows moderate affinity (Ki of 300 nM) for human and rat α2 adrenergic receptor[1].
CAS Number
1210-81-7
UNSPSC
12352005
Hazard Statement
H302
Target
5-HT Receptor; Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/st1936.html
Purity
99.70
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N1)=C(CCN(C)C)C2=C1C=CC(Cl)=C2
Molecular Formula
C13H17ClN2
Molecular Weight
236.74
Precautions
P264-P270-P330-P501
References & Citations
[1]Borsini F, et al. Effects of ST1936, a selective serotonin-6 agonist, on electrical activity of putative mesencephalic dopaminergic neurons in the rat brain. J Psychopharmacol. 2015 Jul;29 (7) :802-11.|[2]Riccioni T, et al. ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors. Eur J Pharmacol. 2011;661 (1-3) :8-14. |[3]Tassone A, et al. Activation of 5-HT6 receptors inhibits corticostriatal glutamatergic transmission. Neuropharmacology. 2011;61 (4) :632-637. |[4]Valentini V, et al. A microdialysis study of ST1936, a novel 5-HT6 receptor agonist. Neuropharmacology. 2011;60 (4) :602-608.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor;5-HT6 Receptor;5-HT7 Receptor; MUC2; MUC3; α adrenergic receptor; α-1 microglobulin

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