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TCS2002

CAT: 0804-HY-10096-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10096-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TCS2002 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC50 of 35 nM. TCS2002 shows good pharmacokinetic profiles including favorable BBB penetration. TCS2002 can be used for the research of Alzheimer’s disease[1].
CAS Number
1005201-24-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tcs2002.html
Purity
99.80
Solubility
DMSO : 34 mg/mL (ultrasonic; warming)
Smiles
O=S(C)C1=CC=C(C=C1)C2=COC3=CC=C(C4=NN=C(C)O4)C=C23
Molecular Formula
C18H14N2O3S
Molecular Weight
338.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Morihisa Saitoh, et al. 2-{3-[4- (Alkylsulfinyl) phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability. J Med Chem. 2009 Oct 22;52 (20) :6270-86.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3

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