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Echinatin

CAT: 0804-HY-N0269-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0269-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Echinatin is a chalcone isolated from the Chinese herbal medicine Gancao with hepatoprotective and anti-inflammatory effects[1]. Echinatin can be quickly absorbed and eliminated and extensively distributed with an absolute bioavailability of approximately 6.81% in Rat[2].
CAS Number
34221-41-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; NOD-like Receptor (NLR)
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/echinatin.html
Concentration
10mM
Purity
99.83
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(O)C=C1)/C=C/C2=CC=C(O)C=C2OC
Molecular Formula
C16H14O4
Molecular Weight
270.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Liang M, et al. Antioxidant Mechanisms of Echinatin and Licochalcone A. Molecules. 2018 Dec 20;24 (1) .|[2]Xu G, et al. Echinatin effectively protects against NLRP3 inflammasome-driven diseases by targeting HSP90. JCI Insight. 2021 Jan 25;6 (2) :e134601.|[3]Niu J, et al. Cardioprotective Effect of Echinatin Against Ischemia/Reperfusion Injury: Involvement of Hippo/Yes-Associated Protein Signaling. Front Pharmacol. 2021 Jan 11;11:593225.|[4]Hong P, et al. Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis. Cell Death Dis. 2020 Jul 13;11 (7) :524.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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Alternative Products

CatalogName
MBS3608440-01Echinatin
A14853-25Echinatin 25mg
A14853-1Echinatin 1mg
A14853-500Echinatin 500mg
A14853-100Echinatin 100mg
A14853-50Echinatin 50mg
A14853-10Echinatin 10mg
A14853-5Echinatin 5mg
A14853-10mM-DEchinatin 10mM * 1mL in DMSO

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