Products for Research Use Only

M4K2281

CAT: 0804-HY-161376Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-161376Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
M4K2281 is a selecitve inhibitor for activin receptor-like kinase-2 (ALK2) with an IC50 of 2 nM. M4K2281 exhibits a moderate blood brain permeability with a brain to plasma ratio of 3.7 at 4h[1].
UNSPSC
12352005
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/m4k2281.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(CC1)C2=CC=C3C(OCCC4=C3C=NC=C4C5=CC(OC)=C(C(OC)=C5)OC)=C2
Molecular Formula
C27H31N3O4
Molecular Weight
461.55
References & Citations
[1]González-Álvarez H, et al., Discovery of Conformationally Constrained ALK2 Inhibitors. J Med Chem. 2024 Mar 28;67 (6) :4707-4725.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALK2; ALK5

Related Products

Alternative Products