Samidorphan

CAT: 0804-HY-123689-03Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-123689-03Size:10 mg

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Description

Samidorphan (ALKS-33) is an orally active opioid system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan primarily acts as an opioid receptor antagonist in vivo. Samidorphan can improve the behavior of depressed animals[1][2][3][4][5].

CAS Number

852626-89-2

Product Name Alternative

ALKS-33; RDC-0313

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/samidorphan.html

Concentration

10mM

Purity

99.04

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(N)C1=CC=C(C[C@H]([C@@]2(CC3)O)N(CC4)CC5CC5)C([C@]42CC3=O)=C1O

Molecular Formula

C21H26N2O4

Molecular Weight

370.44

References & Citations

[1]McElroy SL, et al. A placebo-controlled pilot study of the novel opioid receptor antagonist ALKS-33 in binge eating disorder. Int J Eat Disord. 2013 Apr;46 (3) :239-45.|[2]Mark S. Todtenkopf, et al. Buprenorphine in Combination with Samidorphan (ALKS 33) Results in Antidepressive-Like Effects in Two Distinct Rat Models. Eur Neuropsychopharmacol. 2014;24aSuppl 2) :S366.|[3]Rehan ST, et al. Samidorphan/olanzapine combination therapy for schizophrenia: Efficacy, tolerance and adverse outcomes of regimen, evidence-based review of clinical trials. Ann Med Surg (Lond) . 2022 Jun 30;79:104115.|[4]Shravni V, et al. Comparative Effects of Buprenorphine and Samidorphan on Locomotor Behavior in vivo. Scientific Research Journal of Pharmacy 2021, Volume 1, Issue: 1 (June-July) . |[5]Smith KL, et al. Opioid system modulators buprenorphine and samidorphan alter behavior and extracellular neurotransmitter concentrations in the Wistar Kyoto rat. Neuropharmacology. 2019 Mar 1;146:316-326.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Chemical Information

Samidorphan

Samidorphan is a member of phenanthrenes.

CAS Number	852626-89-2
PubChem CID	11667832
IUPAC Name	(1R,9R,10S)-17-(cyclopropylmethyl)-3,10-dihydroxy-13-oxo-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene-4-carboxamide
Molecular Formula	C21H26N2O4
Molecular Weight	370.4
XLogP	1.1
Topological Polar Surface Area	104
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Heavy Atom Count	27
Formal Charge	0
Complexity	665

SMILES

C1CC1CN2CC[C@]34CC(=O)CC[C@]3([C@H]2CC5=C4C(=C(C=C5)C(=O)N)O)O

InChI

InChI=1S/C21H26N2O4/c22-19(26)15-4-3-13-9-16-21(27)6-5-14(24)10-20(21,17(13)18(15)25)7-8-23(16)11-12-1-2-12/h3-4,12,16,25,27H,1-2,5-11H2,(H2,22,26)/t16-,20-,21-/m1/s1

InChIKey

RYIDHLJADOKWFM-MAODMQOUSA-N

Chemical Structure

2D Structure

CAS: 852626-89-2

CID: 11667832

Formula: C21H26N2O4

MW: 370.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	370.4
XLogP3	1.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	370.18925731
Monoisotopic Mass	370.18925731
Topological Polar Surface Area	104 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	665
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
BA5654-10	Samidorphan
TMIH-0515-01	Samidorphan-d5
MBS5810464	Iso-Samidorphan
GTR19219644-01	Samidorphan HCl
CS-O-48815	Samidorphan-d4
MBS5813505	Olanzapine/Samidorphan
RM-S012107-01	Samidorphan Impurity 7
TRC-H299880-10MG	10-Hydroxy Samidorphan
AR-S09523-01	Samidorphan L-malate
TRC-O311990-50MG	10-Oxo Samidorphan

Samidorphan

Chemical Information

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