Clocortolone

• Description:

  Clocortolone is a synthetic glucocorticoid steroid and corticosteroid ester. Clocortolone can be used for seborrheic dermatitis, contact dermatitis, atopic dermatitis, and psoriasis. Clocortolone has local in vivo potency and is not easily absorbed into systemic circulation[1].

• UNSPSC:

  12352211

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Drug Metabolite

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/clocortolone.html

• Smiles:

  C[C@@]12[C@@H] (C (CO) =O) [C@H] (C) C[C@@]1 ([H]) [C@]3 ([H]) C[C@H] (F) C4=CC (C=C[C@]4 (C) [C@@]3 (Cl) [C@@H] (O) C2) =O

• Molecular Formula:

  C22H28ClFO4

• Molecular Weight:

  410.91

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Singh S, et al. Clinical utility of clocortolone pivalate for the treatment of corticosteroid-responsive skin disorders: a systematic review[J]. Clinical, Cosmetic and Investigational Dermatology, 2012: 61-68.|[2]Kircik LH, et al. The treatment of inflammatory facial dermatoses with topical corticosteroids: focus on clocortolone pivalate 0.1% cream. J Drugs Dermatol. 2012 Oct;11 (10) :1194-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  4828-27-7