Sphingosine-1-phosphate
CAT:
804-HY-108496-02
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Sphingosine-1-phosphate
- CAS Number: 26993-30-6
- UNSPSC Description: Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2]. Sphingosine-1-phosphate stimulates the DNA synthesis, cell proliferation and migration[4].
- Target Antigen: Endogenous Metabolite; LPL Receptor
- Type: Natural Products
- Related Pathways: GPCR/G Protein;Metabolic Enzyme/Protease
- Applications: Metabolism-sugar/lipid metabolism
- Field of Research: Cancer; Endocrinology; Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/Sphingosine-1-phosphate.html
- Purity: 99.0
- Solubility: 1 M NaOH : 33.33 mg/mL (ultrasonic)|DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C)|Methanol : 3.85 mg/mL (ultrasonic;warming;adjust pH to 3 with 1M HCl;heat to 60°C)
- Smiles: N[C@@H](CO[P](O)(O)=O)[C@H](O)/C=C/CCCCCCCCCCCCC
- Molecular Weight: 379.47
- References & Citations: [1]Teresa Sanchez, et al. Structural and Functional Characteristics of S1P Receptors. J Cell Biochem. 2004 Aug 1;92(5):913-22.|[2]Kirsten Uhlenbrock, et al. Sphingosine 1-phosphate Is a Ligand of the Human gpr3, gpr6 and gpr12 Family of Constitutively Active G Protein-Coupled Receptors. Cell Signal. 2002 Nov;14(11):941-53.|[3]S An, et al. Transduction of Intracellular Calcium Signals Through G Protein-Mediated Activation of Phospholipase C by Recombinant Sphingosine 1-phosphate Receptors. Mol Pharmacol. 1999 May;55(5):787-94|[4]Calise S, et al., Sphingosine 1-phosphate stimulates proliferation and migration of satellite cells: role of S1P receptors. Biochim Biophys Acta. 2012 Feb;1823(2):439-50.
- Shipping Conditions: Blue Ice
- Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
- Clinical Information: Phase 1