KMS88009

CAT: 0804-HY-118243Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-118243Size:1 Each

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Description

KMS88009 is a potent small molecule that directly interferes with the formation of amyloid-β oligomers, thereby preserving cognitive behavior when used preventively and reversing cognitive behavior decline when used therapeutically. Oral administration of KMS88009 around the onset of Alzheimer's disease symptoms significantly reduced the assembly of amyloid-β oligomers and improved cognitive behavior in the APP/PS1 double transgenic mouse model. This unique dual mode of action suggests that KMS88009 may be a powerful therapeutic candidate for the treatment of Alzheimer's disease. In an evaluation, the physicochemical properties, pharmacokinetics and toxicity of this anti-amyloidogenic small molecule KMS88009 were studied, as well as post-mortem analysis of APP/PS1 TG mice after behavioral testing.

CAS Number

1089681-42-4

UNSPSC

12352005

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/kms88009.html

Smiles

CN(C)C1=CC=C(/C=C/C2=CC3=CC=C(C=C3O2)OC)C=C1

Molecular Formula

C19H19NO2

Molecular Weight

293.36

References & Citations

[1]Aminostyrylbenzofuran Directly Reduces Oligomeric Amyloid-b and Reverses Cognitive Deficits in Alzheimer Transgenic Mice

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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