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AMB639752

CAT: 0804-HY-156567-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-156567-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMB639752 is a potent DGKα inhibitor. AMB639752 restores restimulation induced cell death (RICD) in SAP deficient lymphocytes by inhibiting DGKα in intact cells. AMB639752 can be used for X-linked lymphoproliferative disease 1 (XLP-1) research[1].
CAS Number
371210-26-3
UNSPSC
12352005
Target
DGK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/amb639752.html
Purity
99.04
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CO1)N2CCN(CC(C3=C(C)NC4=C3C=CC(C)=C4)=O)CC2
Molecular Formula
C21H23N3O3
Molecular Weight
365.43
References & Citations
[1]Velnati S, et.al. Identification of a novel DGKα inhibitor for XLP-1 therapy by virtual screening. Eur J Med Chem. 2019 Feb 15;164:378-390.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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