Picolinamide (Standard)

• Description :

  Picolinamide (Standard) is the analytical standard of Picolinamide. This product is intended for research and analytical applications. Picolinamide (2-Picolinamide) is an inhibitor of Poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells[1][3].

• Product Name Alternative :

  2-Picolinamide (Standard)

• UNSPSC :

  12352005

• Target :

  PARP; Reference Standards

• Type :

  Reference Standards

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics; Others

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/picolinamide-standard.html

• Smiles :

  O=C(C1=NC=CC=C1)N

• Molecular Formula :

  C6H6N2O

• Molecular Weight :

  122.12

• References & Citations :

  [1]Campbell PI, et al. Specific inhibition of rat renal Na+/phosphate cotransport by picolinamide. J Pharmacol Exp Ther. 1989 Oct;251 (1) :188-92. |[2]Uchigata Y, et al. Protection by superoxide dismutase, catalase, and poly (ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J Biol Chem. 1982 Jun 10;257 (11) :6084-8. |[3]Yamamoto H, et al. Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets. Biochem Biophys Res Commun. 1980 Jul 16;95 (1) :474-81. |[4]amagami T, et al. Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly (adenosine diphosphate ribose) synthetase inhibitors. Cancer Res. 1985 Apr;45 (4) :1845-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• Clinical Information :

  No Development Reported

• CAS Number :

  [1452-77-3]