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Variabilin

CAT: 0804-HY-167686Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-167686Size:1 Each
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Description
Variabilin (Homopisatin) is a potent RGD-containing antagonist of glycoprotein IIb-IIIa and platelet aggregation inhibitor from the hard tick Dermacentor variabilis. Variabilin potently inhibits platelet aggregation induced by the platelet agonists ADP, collagen, and thrombin receptor peptide SFLLRNP. Variabilin also blocks platelet adhesion to immobilized Fg. In addition, Variabilin inhibits binding of purified human GPIIb-IIIa to immobilized Fg[1][2].
CAS Number
3187-52-8
Product Name Alternative
Homopisatin
UNSPSC
12352005
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/variabilin.html
Smiles
O[C@@]12[C@@](OC3=CC(OC)=CC=C32)([H])C4=CC=C(OC)C=C4OC1
Molecular Formula
C17H16O5
Molecular Weight
300.31
References & Citations
[1]Wang X, et al. Variabilin, a novel RGD-containing antagonist of glycoprotein IIb-IIIa and platelet aggregation inhibitor from the hard tick Dermacentor variabilis. J Biol Chem. 1996 Jul 26;271 (30) :17785-90. |[2]Kurosawa K, et al. Variabilin, a 6a-hydroxypterocarpan from Dalbergia variabilis[J]. Phytochemistry, 1978, 17 (8) : 1417-1418.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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