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Firategrast

CAT: 0804-HY-14951-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14951-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist. Firategrast reduces trafficking of lymphocytes into the central nervous system (CNS) and decreases multiple sclerosis (MS) activity[1][2][3].
CAS Number
402567-16-2
Product Name Alternative
SB 683699
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Firategrast.html
Purity
99.75
Solubility
DMSO : ≥ 100 mg/mL|Ethanol : ≥ 50 mg/mL
Smiles
O=C(O)[C@@H](NC(C1=C(F)C=CC=C1F)=O)CC2=CC=C(C3=C(OC)C=C(COCC)C=C3OC)C=C2
Molecular Formula
C27H27F2NO6
Molecular Weight
499.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Moses O. Evbuomwan, et al. Generation and Characterization of Novel VLA-4 Inhibitors for Stem Cell Mobilization in Combination with a CXCR2 Agonist. Blood (2017) 130 (Supplement 1) : 3197.|[2]Sarah E M Herman, et al. Treatment with Ibrutinib Inhibits BTK- and VLA-4-Dependent Adhesion of Chronic Lymphocytic Leukemia Cells In Vivo. Clin Cancer Res. 2015 Oct 15;21 (20) :4642-51.|[3]Eva Szenes, et al. TCL1 transgenic mice as a model for CD49d-high chronic lymphocytic leukemia. Leukemia. 2020 Sep;34 (9) :2498-2502.|[4]H Rahimi, et al. Aberrant regulation of the integrin very late antigen-4 in systemic lupus erythematosus. Lupus. 2013 Mar;22 (3) :297-306.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
α4β1; α4β7

Alternative Products

CatalogName
GTR19178862-01Firategrast
MBS130659-01SB-683699?Firategrast
MBS386128-01Firategrast (SB 683699)
A12787-100Firategrast (SB 683699) 100mg
A12787-25Firategrast (SB 683699) 25mg
A12787-50Firategrast (SB 683699) 50mg
A12787-1Firategrast (SB 683699) 1mg
A12787-200Firategrast (SB 683699) 200mg
A12787-5Firategrast (SB 683699) 5mg
A12787-10Firategrast (SB 683699) 10mg

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