J5 peptide

• Description:

  J5 peptide is an MBP inhibitor that competitively inhibits the binding of MBP85-99 to HLA-DR2. J5 peptide alleviates PLP139-151/MBP85-99-induced experimental autoimmune encephalomyelitis (EAE) in mice. J5 peptide can be used in research on inflammatory and immune diseases[1].

• Product Name Alternative:

  Myelin basic protein (85-99) antagonist

• UNSPSC:

  12352209

• Target:

  Biochemical Assay Reagents

• Type:

  Peptides

• Related Pathways:

  Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/j5-peptide.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC(CC[C@H](N)C(N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(N2[C@@H](CCC2)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)CC3=CC=C(C=C3)O)=O)=O)=O)=O)=O)=O)=O)=O

• Molecular Formula:

  C70H114N18O21

• Molecular Weight:

  1543.76

• References & Citations:

  [1]Smith CE, et al. Differential induction of IgE-mediated anaphylaxis after soluble vs. cell-bound tolerogenic peptide therapy of autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2005 Jul 5;102 (27) :9595-600.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  [444305-16-2]