Mitoquinol

• Description:

  Mitoquinol is an orally active mitochondria-targeted antioxidant. Mitoquinol can regulate mitochondrial respiration and oxidation. Mitoquinol inhibits ROS production, and improves phagocytosis and glycolysis in ethanol-exposed macrophages via the HIF-1α-PFKP axis. Additionally, Mitoquinol can partially alleviate heat stress-induced decreases in growth performance, inflammatory responses, and metabolic disorders in pigs[1][2][3].

• UNSPSC:

  12352005

• Target:

  HIF/HIF Prolyl-Hydroxylase; Reactive Oxygen Species (ROS)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/mitoquinol.html

• Purity:

  98.00

• Solubility:

  DMSO : 30 mg/mL (ultrasonic; warming)

• Smiles:

  CC1=C (CCCCCCCCCC[P+] (C2=CC=CC=C2) (C3=CC=CC=C3) C4=CC=CC=C4) C (O) =C (OC) C (OC) =C1O.CS (=O) ([O-]) =O

• Molecular Formula:

  C38H49O7PS

• Molecular Weight:

  680.83

• References & Citations:

  [1]Fink BD, et al. Bioenergetic effects of mitochondrial-targeted coenzyme Q analogs in endothelial cells. J Pharmacol Exp Ther. 2012 Sep;342 (3) :709-19. |[2]Mayorga EJ, et al. Therapeutic effects of mitoquinol during an acute heat stress challenge in growing barrows. J Anim Sci. 2024 Jan 3;102:skae161.|[3]Pant BD, et al. Mitoquinol improves phagocytosis and glycolysis in ethanol-exposed macrophages via HIF-1α-PFKP axis. J Immunol. 2025 May 12:vkaf078.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  845959-55-9