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Mitoquinol

CAT: 0804-HY-124410-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124410-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mitoquinol is an orally active mitochondria-targeted antioxidant. Mitoquinol can regulate mitochondrial respiration and oxidation. Mitoquinol inhibits ROS production, and improves phagocytosis and glycolysis in ethanol-exposed macrophages via the HIF-1α-PFKP axis. Additionally, Mitoquinol can partially alleviate heat stress-induced decreases in growth performance, inflammatory responses, and metabolic disorders in pigs[1][2][3].
CAS Number
845959-55-9
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mitoquinol.html
Purity
98.00
Solubility
DMSO : 30 mg/mL (ultrasonic; warming)
Smiles
CC1=C(CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C(O)=C(OC)C(OC)=C1O.CS(=O)([O-])=O
Molecular Formula
C38H49O7PS
Molecular Weight
680.83
References & Citations
[1]Fink BD, et al. Bioenergetic effects of mitochondrial-targeted coenzyme Q analogs in endothelial cells. J Pharmacol Exp Ther. 2012 Sep;342 (3) :709-19. |[2]Mayorga EJ, et al. Therapeutic effects of mitoquinol during an acute heat stress challenge in growing barrows. J Anim Sci. 2024 Jan 3;102:skae161.|[3]Pant BD, et al. Mitoquinol improves phagocytosis and glycolysis in ethanol-exposed macrophages via HIF-1α-PFKP axis. J Immunol. 2025 May 12:vkaf078.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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