Deoxysappanone B

CAT: 0804-HY-N1818-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N1818-01Size:1 mg
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Description
Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan) . Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK) -NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage[1].
CAS Number
[113122-54-6]
Product Name Alternative
3-Deoxysappanone B
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
P38 MAPK
Type
Natural Products
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/deoxysappanone-b.html
Solubility
10 mM in DMSO
Smiles
O=C1[C@H](CC2=CC=C(O)C(O)=C2)COC3=CC(O)=CC=C13
Molecular Formula
C16H14O5
Molecular Weight
286.28
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Ke-Wu Zeng, et al. Deoxysappanone B, a homoisoflavone from the Chinese medicinal plant Caesalpinia sappan L., protects neurons from microglia-mediated inflammatory injuries via inhibition of IκB kinase (IKK) -NF-κB and p38/ERK MAPK pathways. Eur J Pharmacol. 2015 Feb 5;748:18-29.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
MBS57599943-Deoxysappanone B

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