NGP555

CAT: 0804-HY-108714-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-108714-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

NGP555 is a γ-secretase modulator. NGP555 Lowers the Amyloid Biomarker Aβ42[1].

CAS Number

1304630-27-0

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

γ-secretase

Type

Reference compound

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/NGP555.html

Purity

98.77

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CC1=CN(C2=CC=C(C3=CSC(NC4=CC(CC)=C(C)C=C4C)=N3)C=C2F)C=N1

Molecular Formula

C23H23FN4S

Molecular Weight

406.52

Precautions

H302, H315, H319

References & Citations

[1]Kounnas MZ, et al. NGP 555, a γ-Secretase Modulator, Lowers the Amyloid Biomarker, Aβ42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents. Alzheimers Dement (N Y) . 2017 Jan;3 (1) :65-73.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

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