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FRα-targeting peptide C7

CAT: 0804-HY-P10501Size: 1 EachDry Ice: NoHazardous: No
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Description
FRα-targeting peptide C7 is a selective peptide ligand for folate receptor α (FRα) that has specific binding to FRα expressing cells and in vivo tumor targeting ability. FRα-targeting peptide C7 can be used in the research of tumor diagnosis and treatment[1].
CAS Number
2159055-74-8
UNSPSC
12352209
Target
Antifolate
Type
Peptides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/frα-targeting-peptide-c7.html
Smiles
O=C(N[C@@H](CC1=CNC=N1)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N2[C@@H](CCC2)C(NCC(N[C@@H](CC3=CNC4=CC=CC=C34)C(NCC(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCSC)N
Molecular Formula
C62H90N18O16S
Molecular Weight
1375.55
References & Citations
[1]Junxing Li, et al. Identification of a peptide for folate receptor alpha by phage display and its tumor targeting activity in ovary cancer xenograft[J]. Scientific reports, 2018, 8 (1) : 8426.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

FR|A-targeting peptide C7
CAS Number2159055-74-8
PubChem CID171904660
IUPAC Name(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoic acid
Molecular FormulaC62H90N18O16S
Molecular Weight1375.6
XLogP-4.5
Topological Polar Surface Area569
Hydrogen Bond Donor Count19
Hydrogen Bond Acceptor Count20
Rotatable Bond Count39
Heavy Atom Count97
Formal Charge0
Complexity2710
SMILES
C[C@H]([C@@H](C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)NCC(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@H](CCSC)N)O
InChI
InChI=1S/C62H90N18O16S/c1-32(2)22-43(55(89)78-47(30-81)61(95)96)77-54(88)42(12-8-19-67-62(64)65)75-56(90)44(23-35-14-16-38(83)17-15-35)73-49(84)28-69-53(87)45(24-36-26-68-41-11-7-6-10-39(36)41)74-50(85)29-70-58(92)48-13-9-20-80(48)60(94)33(3)72-59(93)51(34(4)82)79-57(91)46(25-37-27-66-31-71-37)76-52(86)40(63)18-21-97-5/h6-7,10-11,14-17,26-27,31-34,40,42-48,51,68,81-83H,8-9,12-13,18-25,28-30,63H2,1-5H3,(H,66,71)(H,69,87)(H,70,92)(H,72,93)(H,73,84)(H,74,85)(H,75,90)(H,76,86)(H,77,88)(H,78,89)(H,79,91)(H,95,96)(H4,64,65,67)/t33-,34+,40-,42-,43-,44-,45-,46-,47-,48-,51-/m0/s1
InChIKey
YKOPPKJNMXOACU-NFDCKIFHSA-N
Chemical Structure
2D Structure
2D structure of FR|A-targeting peptide C7
CAS: 2159055-74-8
CID: 171904660
Formula: C62H90N18O16S
MW: 1375.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1375.6
XLogP3-4.5
Hydrogen Bond Donor Count19
Hydrogen Bond Acceptor Count20
Rotatable Bond Count39
Exact Mass1374.65029003
Monoisotopic Mass1374.65029003
Topological Polar Surface Area569 Ų
Heavy Atom Count97
Formal Charge0
Complexity2710
Isotope Atom Count0
Defined Atom Stereocenter Count11
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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