Cyproheptadine (hydrochloride)

Cyproheptadine (hydrochloride)

• CAS Number: 969-33-5
• UNSPSC Description: Cyproheptadine hydrochloride is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine hydrochloride has antiplatelet and thromboprotective activities. Cyproheptadine hydrochloride can be used for the research of thromboembolic disorders[1][2].
• Target Antigen: 5-HT Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease; Cardiovascular Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/Cyproheptadine-hydrochloride.html
• Purity: 99.94
• Solubility: DMSO : 50 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL
• Smiles: CN1CC/C(CC1)=C2C3=CC=CC=C3C=CC4=CC=CC=C/24.Cl
• Molecular Weight: 323.86
• References & Citations: [1]Calka O, et, al. Effect of cyproheptadine on serum leptin levels. Adv Ther, 2005. 22(5): p. 424-8.|[2]Olivia A Lin, et al. The Antidepressant 5-HT2A Receptor Antagonists Pizotifen and Cyproheptadine Inhibit Serotonin-Enhanced Platelet Function. PLoS One. 2014; 9(1): e87026.Cureus. 2023 Nov 27;15(11):e49530.|PLoS Negl Trop Dis. 2019 Aug 20;13(8):e0007681. |Front Pharmacol. 2021 Apr 12;12:634097.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: Launched