[Lys8, Lys9]-Neurotensin (8-13)

[Lys8, Lys9]-Neurotensin (8-13)

• CAS Number: 139026-64-5
• UNSPSC Description: [Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with Ki values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively[1].
• Target Antigen: Neurotensin Receptor
• Type: Peptides
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/lys8-lys9-neurotensin-8-13.html
• Purity: 99.98
• Solubility: H2O : 100 mg/mL (ultrasonic)
• Smiles: CC(C)C[C@@H](C(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC1=CC=C(O)C=C1)NC([C@H]2N(C([C@H](CCCCN)NC([C@H](CCCCN)N)=O)=O)CCC2)=O)=O)=O
• Molecular Weight: 761.00
• References & Citations: [1]Emilie Eiselt, et al. Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia. ACS Chem Neurosci. 2019 Nov 20;10(11):4535-4544.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
• Clinical Information: No Development Reported