MYC degrader 1 (TFA)
CAT:
804-HY-162318A-02
Size:
10 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
MYC degrader 1 (TFA)
- UNSPSC Description: MYC degrader 1 TFA (compound A80.2HCl) is an orally available MYC molecular glues degrader with anti-tumor activity. MYC degrader 1 TFA restores pRB1 protein activity and re-establishes sensitivity of MYC overexpressing cancer cells to CDK4/6 inhibitors[1].
- Target Antigen: c-Myc; Molecular Glues
- Type: Reference compound
- Related Pathways: Apoptosis;PROTAC
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/myc-degrader-1-tfa.html
- Solubility: DMSO : 200 mg/mL (ultrasonic)
- Smiles: ClC1=CC(C2=CC(C(F)(F)F)=C(N3CCC(CNCC4=CC(CN(C5C(NC(CC5)=O)=O)C6=O)=C6C=C4)CC3)N=C2)=CC=C1.O=C(O)C(F)(F)F
- Molecular Weight: 740.09
- References & Citations: [1]Ma J, et al. MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation. Nat Commun. 2024 Feb 29;15(1):1871.
- Shipping Conditions: Blue Ice
- Clinical Information: No Development Reported