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CRANAD-2

CAT: 0804-HY-103242-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103242-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CRANAD-2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. CRANAD 2 penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a Kd of 38 nM[1][2].
CAS Number
1193447-34-5
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cranad-2.html
Purity
98.0
Solubility
DMF : 2 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 2.08 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CN(C)C(C=C1)=CC=C1/C=C/C2=O[B+3]([F-])([F-])O=C(/C=C/C3=CC=C(N(C)C)C=C3)[CH-]2
Molecular Formula
C23H25BF2N2O2
Molecular Weight
410.26
Precautions
H315, H319
References & Citations
[1]Ran C, et al. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. J Am Chem Soc. 2009 Oct 28;131 (42) :15257-61. |[2]Ran C, et al. Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species. PLoS One. 2011 Apr 29;6 (4) :e19362.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
TXB44734-01CRANAD 2
S3405-01CRANAD-2
A22076-25CRANAD-2 25mg
A22076-100CRANAD-2 100mg
A22076-50CRANAD-2 50mg
A22076-5CRANAD-2 5mg
A22076-200CRANAD-2 200mg
A22076-2CRANAD-2 2mg
A22076-10CRANAD-2 10mg

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