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Pibrozelesin

CAT: 0804-HY-19137Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-19137Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pibrozelesin (KW 2189 free base) is the derivative of antibiotic Duocarmycin B2. Pibrozelesin exhibits antitumor activity, inhibits proliferation of cell H69 with an IC50 of 1.9 μM. Pibrozelesin induces the DNA strand breaks upon activation via carboxyl esterase[1].
CAS Number
154889-68-6
Product Name Alternative
KW 2189 (free base)
UNSPSC
12352005
Target
Antibiotic
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/pibrozelesin.html
Smiles
BrC[C@H]1C2=C(N(C1)C(C(NC3=C4OC)=CC3=CC(OC)=C4OC)=O)C=C(OC(N5CCN(CC5)C)=O)C6=C2C(C(OC)=O)=C(C)N6
Molecular Formula
C32H36BrN5O8
Molecular Weight
698.56
References & Citations
[1]Ogasawara H, et al., A novel antitumor antibiotic, KW-2189 is activated by carboxyl esterase and induces DNA strand breaks in human small cell lung cancer cells. Jpn J Cancer Res. 1994 Apr;85 (4) :418-25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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