Pibrozelesin

• Description:

  Pibrozelesin (KW 2189 free base) is the derivative of antibiotic Duocarmycin B2. Pibrozelesin exhibits antitumor activity, inhibits proliferation of cell H69 with an IC50 of 1.9 μM. Pibrozelesin induces the DNA strand breaks upon activation via carboxyl esterase[1].

• Product Name Alternative:

  KW 2189 (free base)

• UNSPSC:

  12352005

• Target:

  Antibiotic

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/pibrozelesin.html

• Smiles:

  BrC[C@H]1C2=C (N (C1) C (C (NC3=C4OC) =CC3=CC (OC) =C4OC) =O) C=C (OC (N5CCN (CC5) C) =O) C6=C2C (C (OC) =O) =C (C) N6

• Molecular Formula:

  C32H36BrN5O8

• Molecular Weight:

  698.56

• References & Citations:

  [1]Ogasawara H, et al., A novel antitumor antibiotic, KW-2189 is activated by carboxyl esterase and induces DNA strand breaks in human small cell lung cancer cells. Jpn J Cancer Res. 1994 Apr;85 (4) :418-25.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  154889-68-6