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Recombinant Rat Interleukin-3 beta

CAT: 0355-AP60228Size: InquireDry Ice: NoHazardous: No
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CAT#:0355-AP60228Size:Inquire
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Background
Interleukin-3 (IL-3) is a type of biological signal (cytokine) which is encoded by the IL-3 gene located on chromosome 5 and produced primarily by activated T cells beside human thymic epithelial cells, activated murine mast cells, murine keratinocytes and neurons/astrocytes. It exerts its biological activities through binding to Interleukin-3 receptors included α and β subunits, but sequence analysis revealed a number of features indicative of the presence of only one β-subunit in the rat. Interleukin-3 acts in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Furthermore, rat and human IL-3 share low homology and have not cross species activity.
Product Name Alternative
Hematopoietic Growth Factor, MCGF, Multipotential Colony-stimulating Factor, P-cell-stimulating Factor.
Gene ID
24495
UniProt
P97688
Target
MISDRGSDAH HLLRTLDCRT IALEILVKLP YPQVSGLNNS DDKANLRNST LRRVNLDEFL KSQEEFDSQD TTDIKSKLQK LKCCIPAAAS DSVLPGVYNK DLDDFKKKLR FYVIHLKDLQ PVSVSRPPQP TSSSDNFRPM TVEC
Purification
> 95 % by SDS-PAGE and HPLC analyses.
Endotoxin
Less than 1 EU/ug of rRtIL-3β as determined by LAL method.
Bioactivity
5
Storage Conditions
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Calculated Molecular Weight
Approximately 16.3 kDa, a single non-glycosylated polypeptide chain containing 144 amino acids.
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Host or Source
Escherichia coli

UniProtKB · P97688

Interleukin-3

P97688_RAT · Rattus norvegicus

View on UniProt ↗
Primary accession
P97688
Review status
UniProtKB unreviewed (TrEMBL)
Gene
Il3
Protein existence
2: Evidence at transcript level
Organism
Rattus norvegicus (Rat)
Taxonomy ID
10116
Alternative names
IL-3
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Molecular function

CytokineGrowth factor

PTM

Disulfide bond

Cellular component

Secreted

Domain

Signal

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