TIC10g

CAT: 0804-HY-162649Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-162649Size:1 Each

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Description

TIC10g is a dual inhibitor for toll-like receptor 7 and 9 (TLR7 and TLR9), which inhibits TLR7 and TLR9 mediated TNF-α release in mouse macrophages (IC50 is 14.5 μM and 6.5 μM) and human B lymphocytes (IC50 is 7.69 μM and 11.5 μM) . TIC10g inhibits the activation of NF-κB and MAPK, and exhibits anti-inflammatory activity against systemic lupus erythematosus and rheumatoid arthritis [1].

CAS Number

754998-88-4

UNSPSC

12352005

Target

NF-κB; p38 MAPK; Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; NF-κB

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tic10g.html

Smiles

CN1C(C2=CC=C3C(OCO3)=C2)=CN=C1NCC4=C(OC)C=C(OC)C=C4

Molecular Formula

C20H21N3O4

Molecular Weight

367.40

References & Citations

[1]Haseeb M, et al., Discovery of Novel Small Molecule Dual Inhibitor Targeting Toll-Like Receptors 7 and 9. J Chem Inf Model. 2024 Jun 21.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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