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Mecamylamine

CAT: 0804-HY-B1395ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B1395ASize:1 Each
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Description
Mecamylamine is an orally active, nonselective, noncompetitive nAChR antagonist. Mecamylamine is also a ganglionic blocker. Mecamylamine can across the blood-brain barrier. Mecamylamine can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area[1][2][5].
CAS Number
60-40-2
UNSPSC
12352211
Hazard Statement
H315, H319, H320
Target
Histamine Receptor; nAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mecamylamine.html
Purity
90.0
Solubility
10 mM in DMSO
Smiles
CC1(C)C(NC)(C)C2CCC1C2
Molecular Formula
C11H21N
Molecular Weight
167.29
Precautions
H315, H319, H320
References & Citations
[1]Omar Hernández-González, et al. Mechanisms of stimulatory effects of mecamylamine on the dorsal raphe neurons. Brain Res Bull. 2020 Nov;164:289-298. |[2]C P Robinson, et al. The influence of mecamylamine on contractions induced by different agonists and on the role of calcium ions in the isolated rabbit aorta. J Pharmacol Exp Ther. 1976 Apr;197 (1) :57-65. |[3]Mahadevappa P Badanavalu, et al. Nicotine is neuroprotective to neonatal neurons of sympathetic ganglion in rat. Auton Neurosci. 2019 Jan;216:25-32. |[4]Katsuji Kiuchi, et al. Mecamylamine suppresses Basal and nicotine-stimulated choroidal neovascularization. Invest Ophthalmol Vis Sci. 2008 Apr;49 (4) :1705-11. |[5]Rabenstein RL, et al. The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacology (Berl) . 2006 Dec;189 (3) :395-401.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Nat Commun. 2023 Apr 17;14 (1) :2182.|Acta Pharmacol Sin. 2024 Jun;45 (6) :1160-1174.|bioRxiv. 2023 Jul 6.|bioRxiv. 2024 November 03.|Cell Biosci. 2024 Dec 3;14 (1) :146.

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