Dalcotidine

• Description :

  Dalcotidine (KU-1257) is an orally active and competitive histamine H2 receptor antagonist. Dalcotidine promotes the healing of chronic ulcers and inhibits gastric acid secretion[1][2].

• Product Name Alternative :

  KU-1257

• UNSPSC :

  12352005

• Target :

  Histamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/dalcotidine.html

• Smiles :

  O=C(NCCCOC1=CC=CC(CN2CCCCC2)=C1)NCC

• Molecular Formula :

  C18H29N3O2

• Molecular Weight :

  319.44

• References & Citations :

  [1]Sekiguchi H, et al. Healing-promoting action of the new histamine H2-receptor antagonist N-ethyl-N'-[3-[3- (piperidinomethyl) phenoxy]propyl]urea with dual action on chronic gastric and duodenal ulcers induced by acetic acid in rats. Arzneimittelforschung. 1993;43 (2) :139-143. |[2]Sekiguchi H, et al. Effects of the new histamine H2-receptor antagonist N-ethyl-N'-[3-[3- (piperidinomethyl) phenoxy]propyl] urea with potent gastric mucosal protective activity on acute gastric lesions and duodenal ulcers in rats. Arzneimittelforschung. 1993;43 (2) :134-138.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3

• CAS Number :

  [120958-90-9]