(3S,5R)-Fluvastatin-d6 (sodium)

(3S,5R)-Fluvastatin-d6 (sodium)

• CAS Number: 2249799-35-5
• UNSPSC Description: (3S,5R)-Fluvastatin-d6 (sodium) is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1].
• Target Antigen: HMG-CoA Reductase (HMGCR)
• Type: Isotope-Labeled Compounds
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer; Cardiovascular Disease
• Solubility: 10 mM in DMSO
• Smiles: FC1=CC=C(C2=C(/C=C/[C@H](O)C[C@H](O)CC(O[Na])=O)N(C(C([2H])([2H])[2H])C([2H])([2H])[2H])C3=C2C=CC=C3)C=C1
• Molecular Weight: 439.48
• References & Citations: [1]Araújo FA, Rocha MA, Capettini LS, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice. APMIS. 2012 24.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported