SC4453

CAT: 0804-HY-125337Size: InquireDry Ice: NoHazardous: No

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CAT#:0804-HY-125337Size:Inquire

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

59712-21-9

UNSPSC Description

SC4453 is a digoxin analogue in which the lactone ring at C17β is replaced by a pyrazine ring. SC4453 is slightly inferior to digoxin in inhibiting (Na+ + K+)-ATPase, but shows similar sensitivity to potassium ions. The differences in the sensitivity of SC4453 to heart and brain tissue from different species are mainly due to differences in its dissociation rate from the receptor. These observations confirm the high sensitivity of the human heart to cardiac glycosides.

Target Antigen

Na+/K+ ATPase

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sc4453.html

Smiles

O=C1OCC([C@H]2CCC3(O)[C@]4([H])CC[C@]5([H])C[C@@H](O[C@@H]6C[C@@H]([C@@H]([C@@H](C)O6)O[C@@H]7C[C@@H]([C@@H]([C@@H](C)O7)O[C@@H]8C[C@@H]([C@@H]([C@@H](C)O8)O)O)O)O)CC[C@]5(C)[C@@]4([H])C[C@@H](OC(C)=O)[C@]23C)=C1

Molecular Weight

822.98

References & Citations

[1]INHIBITION BY DIGOXIN AND SC4453 OF (Na ÷ + K÷)-ATPase PREPARED FROM HUMAN HEART, GUINEA-PIG HEART AND GUINEA-PIG BRAIN

Shipping Conditions

Room temperature

Clinical Information

No Development Reported

SC4453

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