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CWP232228

CAT: 0804-HY-18959-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18959-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 suppresses tumor formation and metastasis without toxicity through the inhibition of the growth of breast and liver cancer stem cells (CSCs) [1].
CAS Number
1144044-02-9
UNSPSC
12352005
Target
Wnt; β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cwp232228.html
Purity
98.31
Solubility
H2O : 62.5 mg/mL (ultrasonic)
Smiles
C=CCN1CC(N([C@@H](CC2=CC=C(OP(O[Na])(O[Na])=O)C=C2)C(N(CC3=CC=CC4=CN(C)N=C43)C5)=O)[C@H]5N1C(NCC6=CC=CC=C6)=O)=O
Molecular Formula
C33H34N7Na2O7P
Molecular Weight
717.62
References & Citations
[1]Jang GB, et al. Wnt/β-Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells. Cancer Res. 2015 Apr 15;75 (8) :1691-702.|[2]Kim JY, et al. Oncotarget. 2016 Apr 12;7 (15) :20395-409. CWP232228 targets liver cancer stem cells through Wnt/β-catenin signaling: a novel therapeutic approach for liver cancer treatment.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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