Spadin

• Description :

  Spadin, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with IC50 value of 10 nM. Spadin enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. Spadin can be used for antidepressant research[1][2].

• UNSPSC :

  12352209

• Target :

  5-HT Receptor; Potassium Channel

• Type :

  Peptides

• Related Pathways :

  GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/spadin.html

• Purity :

  99.84

• Solubility :

  H2O : ≥ 100 mg/mL

• Smiles :

  O=C(N[C@@H](C)C(N1[C@@H](CCC1)C(N[C@@H](CC(C)C)C(N2[C@@H](CCC2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CO)C(NCC(N5[C@@H](CCC5)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CC6=CNC7=CC=CC=C67)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC8=CC=C(C=C8)O)N

• Molecular Formula :

  C96H142N26O22

• Molecular Weight :

  2012.34

• References & Citations :

  [1]Borsotto M, et, al. Targeting two-pore domain K (+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept. Br J Pharmacol. 2015 Feb;172 (3) :771-84. |[2]Mazella J, et, al. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 2010 Apr 13;8 (4) :e1000355.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [1270083-24-3]