TRV055

• Description :

  TRV055 (TRV120055) is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs) . TRV120055 induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. TRV055 activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. TRV055 induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. TRV055 can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses[1][2].

• CAS Number :

  [25849-90-5]

• Product Name Alternative :

  TRV120055

• UNSPSC :

  12352209

• Target :

  Angiotensin Receptor; ERK

• Type :

  Peptides

• Related Pathways :

  GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/trv055.html

• Purity :

  99.47

• Solubility :

  H2O : 33.33 mg/mL (ultrasonic; adjust pH to 2 with 1M HCl)

• Smiles :

  O=C(N(CCC1)[C@@H]1C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)[C@@H](NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](C(C)C)NC(CN)=O)=O)CC(C=C3)=CC=C3O)=O)=O)CC4=CN=CN4

• Molecular Formula :

  C42H57N9O9

• Molecular Weight :

  831.96

• References & Citations :

  [1]Dallagnol JCC, et al. G Protein-Biased Agonists for Intracellular Angiotensin Receptors Promote Collagen Secretion in Myofibroblasts. ACS Chem Biol. 2023 Sep 15;18 (9) :2050-2062. |[2]Parichatikanond W, et al. Gαq protein-biased ligand of angiotensin II type 1 receptor mediates myofibroblast differentiation through TGF-β1/ERK axis in human cardiac fibroblasts. Eur J Pharmacol. 2023 Jul 15;951:175780.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• Isoform :

  AT1 Receptor